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KMID : 0359319830230010069
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Korean Journal of Veterinary Research
1983 Volume.23 No. 1 p.69 ~ p.79
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Histopathological Changes on the Striated Muscle of Rabbits Fed Zinc , Copper and Linoleic Acid
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Abstract
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The present studs was undertaken to observe the histopathological changes on the cardiac and skeletal muscles, and liver of rabbits fed a commercial ration, either alone or with supplements of Zinc (3,000㎎/㎏. of diet, as sulfate), Copper (1,500㎎/㎏. of diet, as sulfate), Linoleic acid (3% of diet), Zinc with Linoleic acid and Copper with Linoleic acid.
In the skeletal muscle, light microscopic changes observed were cloudy swelling, hyaline degeneration, atrophy fragmentation and coagulative necrosis of muscle fibers, and proliferation of fihroblasts and infiltration of mononuclear cells. Especially, in rabbits fed with supplements of Zinc with Linoleic acid and Copper with Linoleic acids calcification with muscle fibers progressing to necrosis were often observed.
In the mrocardium, loss of muscle fibers with necrosis and vacuolization hyaline degeneration, hemorrhage and congestion were observed. In the liver, congestion and necrosis of hepatocytes, and centrilobular necrosis were observed .
Differences of histological changes among the experimental groups was not marked.
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KEYWORD
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